On Directional Selectivity in Vertebrate Retina: An Experimental and Computational Study

Title: en_US On Directional Selectivity in Vertebrate Retina: An Experimental and Computational Study
Creator: en_US Borg-Graham, Lyle J.
Date: 2004-10-20T19:57:21Z
Date Available: 2004-10-20T19:57:21Z
Date Issued: en_US 1992-01-01
Identifier: en_US AITR-1350
uri: http://hdl.handle.net/1721.1/6804
Abstract: en_US This thesis describes an investigation of retinal directional selectivity. We show intracellular (whole-cell patch) recordings in turtle retina which indicate that this computation occurs prior to the ganglion cell, and we describe a pre-ganglionic circuit model to account for this and other findings which places the non-linear spatio-temporal filter at individual, oriented amacrine cell dendrites. The key non-linearity is provided by interactions between excitatory and inhibitory synaptic inputs onto the dendrites, and their distal tips provide directionally selective excitatory outputs onto ganglion cells. Detailed simulations of putative cells support this model, given reasonable parameter constraints. The performance of the model also suggests that this computational substructure may be relevant within the dendritic trees of CNS neurons in general.
Extent: en_US 148 p.; 12400547 bytes; 4859569 bytes
Format: application/postscript; application/pdf
Language: en_US
Relation: en_US AITR-1350
Subject: en_US computational neuroscience; en_US neural modelling; en_US retinaselectrophysiology