Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons

Title: en_US Modelling the Somantic Electrical Response of Hippocampal Pyramidal Neurons
Creator: en_US Borg-Graham, Lyle J.
Date: 2004-10-20T20:22:35Z
Date Available: 2004-10-20T20:22:35Z
Date Issued: en_US 1989-09-01
Identifier: en_US AITR-1161
uri: http://hdl.handle.net/1721.1/7023
Abstract: en_US A modeling study of hippocampal pyramidal neurons is described. This study is based on simulations using HIPPO, a program which simulates the somatic electrical activity of these cells. HIPPO is based on a) descriptions of eleven non-linear conductances that have been either reported for this class of cell in the literature or postulated in the present study, and b) an approximation of the electrotonic structure of the cell that is derived in this thesis, based on data for the linear properties of these cells. HIPPO is used a) to integrate empirical data from a variety of sources on the electrical characteristics of this type of cell, b) to investigate the functional significance of the various elements that underly the electrical behavior, and c) to provide a tool for the electrophysiologist to supplement direct observation of these cells and provide a method of testing speculations regarding parameters that are not accessible.
Extent: 36745155 bytes; 29879792 bytes
Format: application/postscript; application/pdf
Language: en_US
Relation: en_US AITR-1161